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Important safety information for Compounded Semaglutide (GLP-1) Injection

Warning & Precautions:

  • Thyroid C-Cell Tumors: Semaglutide may increase the risk of thyroid C-cell tumors. Inform your healthcare provider if you have a family history of medullary thyroid carcinoma (MTC) or if you have multiple endocrine neoplasia syndrome type 2 (MEN 2).

  • Pancreatitis: There have been reports of acute pancreatitis in patients treated with GLP-1 receptor agonists like semaglutide. If you experience severe abdominal pain, especially radiating to the back, with or without vomiting, seek medical attention immediately.

  • Hypoglycemia: When used with insulin or insulin secretagogues (such as sulfonylureas), the risk of hypoglycemia (low blood sugar) is increased. Monitor your blood sugar levels regularly and discuss any changes with your healthcare provider.

  • Kidney Function: Monitor renal function in patients who experience severe gastrointestinal reactions. Inform your healthcare provider if you have a history of kidney issues.

  • Hypersensitivity Reactions: There have been reports of serious hypersensitivity reactions, including anaphylaxis, in patients receiving semaglutide. If you experience symptoms such as swelling of the face, lips, tongue, or throat, and difficulty breathing, seek emergency medical help.

  • Diabetic Retinopathy Complications: Rapid improvement in blood glucose control has been associated with a temporary worsening of diabetic retinopathy. Monitor for any changes in vision and inform your healthcare provider.

Contraindications:

  • Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2).
  • Known hypersensitivity to semaglutide or any of its components.

Common Side Effects:

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Decreased appetite

Drug Interactions:

Inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements. Semaglutide may interact with other medications, affecting how they work or increasing the risk of side effects.

Administration Instructions:

  • Follow your healthcare provider’s instructions on how to properly administer the injection.
  • Rotate injection sites to avoid tissue damage.
  • Do not share your injection pen with others to prevent infection.

Pregnancy and Breastfeeding:

  • Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The safety of semaglutide in pregnant or breastfeeding women has not been established.

Monitoring:

  • Regularly monitor your blood sugar levels as directed by your healthcare provider.
  • Schedule periodic follow-up appointments to assess your response to treatment and adjust the dosage if necessary.

Reporting of Side Effects:

Report any adverse effects or side effects to your healthcare provider or the FDA at 1-800-FDA-1088.

Always consult your healthcare provider for medical advice and before making any changes to your medication regimen.